Cox7a2 mediates steroidogenesis in TM3 mouse Ley dig cells

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Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells.

AIM To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. METHODS The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed-Express-N1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was stud...

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BACKGROUND Cytokines and hormones, including insulin, are known to modulate the hypothalamic-pituitary-testes axis and steroidogenesis, both centrally and peripherally. In the context of chronic inflammation and hyperinsulinaemia mediating male hypogonadism associated with obesity, metabolic syndrome and type 2 diabetes mellitus, these mechanisms are poorly understood and the impact of cytokine...

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Nicotine induces apoptosis in TM3 mouse Leydig cells.

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ژورنال

عنوان ژورنال: Asian Journal of Andrology

سال: 2006

ISSN: 1008-682X,1745-7262

DOI: 10.1111/j.1745-7262.2006.00178.x